Protein Modification Reagents
Medchemexpress LLC Pomalidomide-PEG4-C2-NH2 | 2225940-52-1 | 95.1% | 492.52 | 50 MG
This synthesized E3 ligase ligand-linker conjugate incorporates a Pomalidomide-based cereblon ligand and a 4-unit PEG linker, utilized in PROTAC technology.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates a cereblon ligand
- Features a 4-unit PEG linker
- Used in PROTAC technology
Medchemexpress LLC HY-112496 100mg Medchemexpress, Cl-C6-PEG4-O-CH2COOH CAS:1799506-30-1 Purity:>98%
Medchemexpress, HY-112496 100mg Cl-C6-PEG4-O-CH2COOH CAS:1799506-30-1 Cl-C6-PEG4-O-CH2COOH (PROTAC Linker 4) is a PEG-based PROTAC linker can be used in the synthesis of chloroalkane-containing PROTACs (HaloPROTACs). Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
eMolecules 1643957-26-9 | Benzyl-PEG3-CH2CO2tBu | Broadpharm | MFCD28122971 | 310.390 | C17H26O5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCc1ccccc1 | 1g | 254745517
Benzyl-PEG3-CH2CO2tBu | Broadpharm | 1643957-26-9 | MFCD28122971 | 310.390 | C17H26O5 | 98.000 | CC(C)(C)OC(=O)COCCOCCOCc1ccccc1 | 1g | 254745517
Medchemexpress LLC Bis-Tos-PEG4 | 37860-51-8 | 502.60 | 100 G
Bis-Tos-PEG4 (PROTAC Linker 16) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Contains two different ligands connected by a linker
- One ligand binds to an E3 ubiquitin ligase
- The other ligand binds to the target protein
- For research use only
Medchemexpress LLC Dbco-nhco-peg4-nh-boc | 1255942-12-1 | MFCD30730371 | >96.0% | 623.74 g/mol | C34H45N3O8 | 25 MG
Dbco-nhco-peg4-nh-boc is a DBCO-functionalized PEG4 linker used for copper-free click chemistry (SPAAC) in bioconjugation, antibody-drug conjugate assembly, and PROTAC synthesis.
- Enables copper-free click chemistry with azide-functionalized molecules.
- Suitable for antibody-drug conjugate and PROTAC linker synthesis.
- Boc-protected amine facilitates selective deprotection and further functionalization.
- Available in small laboratory quantities for research use.
- Stable when stored at recommended temperatures.
Medchemexpress LLC Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA | 2435572-49-7 | 99.28% | 648.58 | 50 MG
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology. At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form usually boasts enhanced water solubility and stability.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates thalidomide based cereblon ligand
- Features a 3-unit PEG linker for PROTAC technology
- Salt form offers enhanced water solubility and stability
- For research use only
Medchemexpress LLC Dspe-peg-fitc | 1000788-53-3 | 25 MG
DSPE-PEG-FITC (MW 10,000) is a fluorescein-labeled PEGylated phospholipid designed for incorporation into lipid bilayers and nanoparticle surfaces to enable fluorescence imaging and tracking. The amphiphilic conjugate self-assembles in aqueous environments and is commonly used in liposome and micelle formulation for research applications.
- Provides fluorescent labeling for liposomes and nanoparticles.
- Amphiphilic structure enables incorporation into bilayers and micelles.
- Average PEG molecular weight of approximately 10,000 Da.
- Facilitates visualization and tracking in imaging assays.
- Supplied as a solid that is light sensitive; store protected from light.
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 100 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Ligands target E3 ubiquitin ligase and target protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Endo-BCN-PEG3-maleimide | 2141976-33-0 | MFCD31811466 | 98.5% | 519.59 g/mol | C26H37N3O8 | 5 MG
endo-BCN-PEG3-maleimide is a heterobifunctional PEG3 linker that pairs an endo-bicyclononyne (BCN) for strain-promoted azide-alkyne cycloaddition with a maleimide for thiol-selective conjugation. The short PEG3 spacer improves solubility and flexibility, making the reagent suitable for bioconjugation, PROTAC linker assembly, and crosslinking in research applications. Supplied as a colorless to light yellow oil with high reported purity and recommended cold storage.
- Strain-promoted azide-alkyne cycloaddition reactivity (BCN).
- Maleimide-based thiol conjugation for cysteine targeting.
- PEG3 spacer improves solubility and flexibility.
- High purity suitable for research use.
- Stable under low-temperature storage conditions.
- Soluble in common organic solvents such as DCM, THF, ACN, DMF, and DMSO.
Medchemexpress LLC Biotin-PEG-azide | 956494-20-5 | MFCD21363314 | 98.7% | 2000 Da | C58H112N6O25S | 25 MG
Biotin-PEG-azide (MW 2000) is a biotin-labeled polyethylene glycol derivative with a terminal azide group designed for efficient azide-alkyne click conjugation. It improves solubility and reduces nonspecific binding while providing a biotin handle for affinity capture and detection. Supplied as a powder, it is commonly used to label proteins, peptides, and probes for biochemical and analytical workflows.
- Biotin tag for streptavidin-based capture and detection.
- Terminal azide for click chemistry conjugation.
- Average molecular weight 2000 Da for spacer and solubility.
- High purity (~98.7%) for reliable labeling.
- Powder form with recommended storage at -20°C.
- Suitable for labeling proteins, peptides, and probes.
eMolecules 2601437-72-1 | SPDP-PEG12-NHS ester | Broadpharm | MFCD13185005 | 912.070 | C39H65N3O17S2 | 95.000 | O=C(CCSSc1ccccn1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 229582557
SPDP-PEG12-NHS ester | Broadpharm | 2601437-72-1 | MFCD13185005 | 912.070 | C39H65N3O17S2 | 95.000 | O=C(CCSSc1ccccn1)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 100mg | 229582557
(=O)=O)c3ccc(cc3C2(C)CCCCCC(=O)NCCCNC(=O)OCCOCCN)S([O-])(=O)=O)N(CCCS(O)(=O)=O)c2ccc(cc12)S(O)(=O)=O | 5mg | 798871050](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472792.JPG-250.jpg)
eMolecules Amine-PEG-Fluor-647 TEA salts, MW 2,000 | Broadpharm |1046.250 | C44H63N5O16S4 | 95.000 | CC1(C)\C(=C/C=C/C=C/C2=[N+](CCCS(O)(=O)=O)c3ccc(cc3C2(C)CCCCCC(=O)NCCCNC(=O)OCCOCCN)S([O-])(=O)=O)N(CCCS(O)(=O)=O)c2ccc(cc12)S(O)(=O)=O | 5mg | 798871050
Amine-PEG-Fluor-647 TEA salts, MW 2,000 | Broadpharm |1046.250 | C44H63N5O16S4 | 95.000 | CC1(C)\C(=C/C=C/C=C/C2=[N+](CCCS(O)(=O)=O)c3ccc(cc3C2(C)CCCCCC(=O)NCCCNC(=O)OCCOCCN)S([O-])(=O)=O)N(CCCS(O)(=O)=O)c2ccc(cc12)S(O)(=O)=O | 5mg | 798871050
![eMolecules 2093197-98-7 | BDP FL-PEG5-acid | Broadpharm | MFCD30723280 | 583.440 | C27H40BF2N3O8 | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCOCCC(O)=O)n1[B-]2(F)F | 1mg | 340376963](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502458130.PNG-250.jpg)
eMolecules 2093197-98-7 | BDP FL-PEG5-acid | Broadpharm | MFCD30723280 | 583.440 | C27H40BF2N3O8 | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCOCCC(O)=O)n1[B-]2(F)F | 1mg | 340376963
BDP FL-PEG5-acid | Broadpharm | 2093197-98-7 | MFCD30723280 | 583.440 | C27H40BF2N3O8 | 95.000 | CC1=CC(C)=[N+]2C1=Cc1ccc(CCC(=O)NCCOCCOCCOCCOCCOCCC(O)=O)n1[B-]2(F)F | 1mg | 340376963
eMolecules 2183440-32-4 | Medchem Express | APN-C3-PEG4-azide | 5mg | 779715127 | HY-140841 | 500.556 | C24H32N6O6
Ambeed | tert-Butyl 4-(4-bromo-2-nitrophenyl)piperazine-1-carboxylate | 100mg | 716529441 | A381595 | 474329-57-2 | MFCD11041977 | 386.246 | C15H20BrN3O4
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eMolecules 2055041-18-2 | Propargyl-PEG4-S-PEG4-t-butyl ester | Broadpharm | MFCD29918244 | 552.720 | C26H48O10S | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCC#C | 250mg | 306709058
Propargyl-PEG4-S-PEG4-t-butyl ester | Broadpharm | 2055041-18-2 | MFCD29918244 | 552.720 | C26H48O10S | 98.000 | CC(C)(C)OC(=O)CCOCCOCCOCCOCCSCCOCCOCCOCCOCC#C | 250mg | 306709058